REFERENCES

A list of selected references is reported.
When indicated, the pdf file is available on request.

The references listed as “CLINICAL AND EXPERIMINTAL” are ordered by publication year

BATROXOBIN

Niewiarowski S, Stewart GJ, Nath N, Sha TA, Liverman E. ADP, thrombin, and Bothrops atrox thrombin-like enzyme in platelet-dependent clot retraction. Am J Physiol 1975;229:737-745 

Kubisz P, Suranova J. Reptilase clot retraction test. Pathol Biol (Paris)1975;23:269-275.

Niewiarowski S, Goldstein S. Fibrin clot retraction by human skin fibroblasts: effects of ADP and thrombin. Proc Soc Exp Biol Med. 1976;151:253-256.

Holleman WH, Weiss LJ. The Thrombin-like Enzyme from Bothrops atrox Snake Venom. 
J Biol Chem 1976; 251:1663-1669

K. Stocker K, Fischer H, Meier J. Thrombin-like snake proteinases. Toxicon, 1982;20:265-273

Hantgan RR, Taylor RG, Lewis JC. Platelets Interact With Fibrin Only After Activation. Blood 1985;65: 1299-1131

Martinowitz U, Schulman S. Fibrin sealant in surgery of patients with a hemorrhagic diathesis. Thromb Haemost 1995;74:486–492.

D. Huang, Y. Fang, S. Jiang, W. Yang, B. Hu, Y. Hu, Y. Li (Institute of Otolaryngology, Chinese PLA General Hospital). Preventative and therapeutic effect of Batroxobin on experimental adhesive otitis. 1998, 487, Session R1, Poster. Association for Research in Otolaryngology (www.aro.org/office.html)

Ortel TL, Mercer MC, Thames EH, Moore KD, Lawson JH. Immunologic impact and clinical outcomes after surgical exposure to bovine thrombin. Ann Surg 2001;233:88–96

Carr ME, Carr SL, Tildon T, et al. Batroxobin-induced clots exhibit delayed and reduced platelet contractile force in some patients with clotting factor deficiencies. J Throm Haemost 2003;1:243-249

Schöni R. The Use of Snake Venom-Derived Compounds for New Functional Diagnostic Test Kits in the Field of Haemostasis. Pathophysiol Haemost Thromb 2005;34:234–240


CLINICAL AND EXPERIMINTAL

1975
Rosenthal AR, Harbury C, Egbert PR, Rubenstein E. Use of a platelet-fibrinogen-thrombin mixture as a corneal adhesive: experiments with sutureless lamellar keratoplasty in the rabbit. Invest Ophthalmol 1975;14:872-875.

1979
Fischer H. A method of suture-free anastomosis of nerve transplantation is being reported, using facial nerve as the example. Laryngol Rhinol Otol (Stuttg)1979;58:154-156 )[article in German]

1986
Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler EL. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg. 1986;204:322-330

1987
Elgin RG, Busby WH Jr, Clemmons DR. An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I. Proc Natl Acad Sci USA 1987:84:3254-3258.

1989
Ross M, Francis GL, Szabo L, Wallace JC, Ballard FJ. Insulin-like growth factor (IGF)-binding proteins inhibit the biological activities of IGF-1 and IGF-2 but not des-(1-3)-IGF-1. Biochem J 1989;258:267-272.

1997
Whitman DH, Berry RL, Green DM. Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg 1997;55:1294-1299

1998
Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-646.

2001
Margolis DJ, Kantor J, Santanna J, Strom BL, Berlin JA. Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 2001; 24: 483–488

Laplante AF, German L, Auger FA, Moulin V. Mechanisms of wound reepithelialization: hints from a tissue-engineered reconstructed skin to long-standing questions. FASEB J 2001;15,2377–2389. 

Gilsanz F, Escalante F, Auray C, Olbés AG. Treatment of leg ulcers in -Thalassemia intermedia: use of platelet-derived wound healing factors from the patient’s own platelets. Br J Haematol 2001;115: 710-714

Ma L, Elliott SN, Cirino G, Buret A, Ignarro LJ, Wallace JL. Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. Proc Natl Acad Sci USA 2001;98:6470-6475

2002
Carlson NE, Roach RB Jr. Platelet-rich plasma clinical applications in dentistry. JADA 2002;133:1383-1386

Gruber R, Varga F, Fischer MB, Watzek G. Platelets stimulate proliferation of bone cells: involvement of platelet derived growth factor, microparticles and membranes. Clin Oral Impl Res. 2002;13: 529–535

2003
Go RS, Ritman EL, Owen WG. Angiogenesis in rat aortic rings stimulated by very low concentrations of serum and plasma. Angiogenesis. 2003;6:25-29 

Carter CA, Jolly DJ, Worden CE Sr, Hendren DG, J.M. Kane CJM. Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Exp Molec Pathol 2003;74:244-245

Gruber R, Karreth F, Frommlet F, Michael B. Fischer MB, Watzek G. Platelets are mitogenic for periosteum-derived cells. J Orthop Res 2003;21:941–948

Fuerst G, Gruber R, Tangl S, Sanroman F, Watzek G. Enhanced Bone-to-Implant Contact by Platelet-Released Growth Factors in Mandibular Cortical Bone: A Histomorphometric Study in Minipigs. Int J Oral Maxillofac Implants 2003;18:685–690

Yazawa M, Ogata H, Nakajima T, Mori T, Watanabe N, Handa M. Basic Studies on the Clinical Applications of Platelet-Rich Plasma. Cell Transplantation 2003;12:509–518

Okuda K, Kawase T, Momose M, Murata M, Saito Y, Suzuki H, Wolff LF, Yoshie H. Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro. J Periodontol. 2003;74:849-857

Soffer E, Ouhayoun J-P, Anagnostou F. Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:521-8

Senet P, Bon F-X, Benbunan M, Bussel A, Traineau R, Calvo F et al. Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers. J Vasc Surg 2003;38: 1342-8.

Kawase T, Okuda K, Wolff LF, Yoshie H. Platelet-rich plasma-derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cells in vitro. J Periodontol 2003;74:858-864

Rodriguez A, Anastassov GE, Lee H, Buchbinder D, Wettan H. Maxillary sinus augmentation with platelet rich plasma with simultaneous insertion of endosseous implants. J Oral Maxillofac Surg 2003;61:157-163

Wachtlin J, Jandeck C, Potthöfer S, Kellner U, Foerster MH. Long-term results following pars plana vitrectomy with platelet concentrate in pediatric patients with traumatic macular hole. Am J Ophthal 2003:136:197-199

Henderson JL, Cupp CL, E. Ross EV, Shick PC, Keefe MA et al. The effects of autologous platelet gel on wound healing. Ear Nose Throat J 2003;82:598-602

Tyndall WA, Beam HA, Zarro C, O’Connor JP, Lin SS. Decreased platelet derived growth factor expression during fracture healing in diabetic animals. Ann Orthop Rel Res 2003;408:319-330 

2004
Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 2004:114:1502-1504

Freymiller EG, Aghaloo TL. Platelet-Rich Plasma: Ready or Not? J Oral Maxillofac Surg 2004;62:484-488 

Mogan C, Larson DF. Rationale of platelet gel to augment adaptive remodeling of the injured heart. J Extra Corpor Technol 2004;36:191-196

Martineau I, Lacoste E, Gagnon G. Effects of calcium and thrombin on growth factor release from platelet concentrates: Kinetics and regulation of endothelial cell proliferation. Biomaterials 2004;25:4489–4502 

Hartwig D, Harloff S, Liu L, Schlenke P, Wedel T, Geerling G. Epitheliotrophic capacity of a growth factor preparation produced from platelet concentrates on corneal epithelial cells: a potential agent for the treatment of ocular surface defects? Transfusion 2004;44:1724-1731 

Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004;91:4-15 

Burnouf T, Radosevich M, Goubran HA. Local hemostatic blood products: fibrin sealant and platelet gel. Treatment of Hemophilia Monographs, Sam Schulman Ed. Published by the World Federation of Hemophilia (WFH). Treatment of Hemophilia, September 2004 

Yamada Y, Ueda M, Naiki T, Takahashi M, Hata K, Nagasaka T. Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet-rich plasma: tissue-engineered bone regeneration. Tissue Eng 2004;10:955-964

Soffer E, Ouhayoun J-P, Dosquet C, Meunier A, Anagnostou F. Effects of platelet lysates on select bone cell functions. Clin Oral Impl Res 2004; 15:581–588 

Borzini P, Mazzucco L, Panizza R, Rivara G. Regarding “Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers. J Vasc Surg 2004;39: 1146-1147 

Gruber R, Karreth F, Kandler B, Fuerst G, Rot A, Fischer MB, Watzek G. Platelet-released supernatants increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under in vitro conditions. Platelets 2004;15:29–35

Schlegel KA, Donath K, Rupprecht S, Falk S. De novo bone formation using bovine collagen and platelet-rich plasma. Biomaterials 2004;25: 5387–5393 

Kandler B, Fischer MB, Watzek G, Gruber R. Platelet-released supernatant increases matrix metalloproteinase-2 production, migration, proliferation, and tube formation of human umbilical vascular endothelial cells. J Periodontol 2004;75:1255-1261 

Yazawa M, Ogata H, Nakajima T, Watanabe N. Influence of Antiplatelet Substances on Platelet-Rich Plasma. J Oral Maxillofac Surg 2004;62:714-718 

Marx RE. Platelet-Rich Plasma: Evidence to Support Its Use. J Oral Maxillofac Surg 2004; 62:489-496 

Oyama T, Nishimoto S, Tsugawa T, Shimizu F. Efficacy of Platelet-Rich Plasma in Alveolar Bone Grafting. J Oral Maxillofac Surg 2004;62:555-558 

Fennis JPM, Stoelinga PJW, Jansen JA. Mandibular reconstruction: a histological and histomorphometric study on the use of autogenous scaffolds, particulate cortico-cancellous bone grafts and platelet rich plasma in goats. Int J Oral Maxillofac Surg 2004; 33: 48–55 

Merkx MAW, Fennis JPM, Verhagen VM, Stoelinga PJW. Reconstruction of the mandible using preshaped 2.3 mm titanium plates, autogenous particulate cortico-cancellous bone grafts and platelet rich plasma: a report on eight patients. Int J Oral Maxillofac Surg 2004; 33: 733–739

Mazzucco L, Medici D, Serra M, Panizza R, Rivara G, et al. The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study. Transfusion 2004;44:1013-1018

2005
Fréchette J-P, Martineau I, Gagnon G. Platelet-rich plasmas: growth factor content and roles in wound healing. J Dent Res 2005; 84:434-439

Dart AJ, Dowling BA, Smith CL. Topical treatments in equine wound management. Vet Clin North Am Equine Pract 2005;21:77-89 

Borzini P, Mazzucco L. Tissue regeneration and in loco administration of platelet derivatives: clinical outcome, heterogeneous products, and heterogeneity of the effector mechanisms. Transfusion 2005;45:1759-1767 

Lucarelli E, Fini M, Beccheroni A, Giavaresi G, Di Bella C et al. Stromal stem cells and platelet-rich plasma improve bone allograft integration. Clin Orthop Rel Res 2005;435:62–68 

Franchini M, Dupplicato P, Ferro I, De Gironcoli M, Aldegheri R. Efficacy of platelet gel in reconstructive bone surgery. Orthopedics 2005;28:161-163.

Barrow CR, Pomeroy GC. Enhancement of syndesmotic fusion rates in total ankle arthroplasty with the use of autologous platelet concentrate. Foot Ankle Int 2005;26:458-461.

Centella T, Oliva E, García JC, Huélamo T, Lamas MJ, Maseda R, Epeldegui A. Tratamiento de las heridas infectadas tras cirugía cardiaca con la utilización de plasma rico en factores de crecimiento. Resultados preliminares. Anal Cirug Card Vascul 2005;11:208-213 

Weibrich G, Kleis WKG, Hitzler WE, Hafner G. Comparison of the platelet concentrate collection system with the plasma-rich-in-growth-factors kit to produce platelet-rich plasma: a technical report. Int J Oral Maxillofac Impants 2005;20:118–123 

Anitua E, Andìa I, Sanchez M, Azofra J, del Mar Zalduendo M, de la Fuente M, Nurden P, Nurden AT. Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res 2005;23:281–286 

Borzini P, Mazzucco L. Platelet gels and releasates. Curr Opin Hematol 2005;12:473-479 

Thorwarth M, Rupprecht S, Falk S, Felszeghy E, Wiltfang J, Schlegel KA. Expression of bone matrix proteins during de novo bone formation using a bovine collagen and platelet-rich plasma (prp) — an immunohistochemical analysis. Biomaterials 2005;26:2575-84 

Fennis JPM, Stoelinga PJW, Jansen JA. Reconstruction of the mandible with an autogenous irradiated cortical scaffold, autogenous corticocancellous bone-graft and autogenous platelet-rich-plasma: an animal experiment. Int J Oral Maxillofac Surg 2005;34:158-166 

Grageda E, Lozada JL, Boyne PJ, Caplanis N, McMillan PJ. Bone formation in the maxillary sinus by using platelet-rich plasma: an experimental study in sheep. J Oral Implantol 2005;31:1-17 

Tsay RC, Vo J, Burke A, Eisig SB, Lu HH, Landesberg R. Differential Growth Factor Retention by Platelet-Rich Plasma Composites. J Oral Maxillofac Surg 2005;63:521-528 

Englert SJ, Estep TH, Ellis-Stoll CC. Autologous platelet gel application during cardiovascular surgery: effect on wound healing. JECT 2005;37:148-152 

Pomerantz J, Dutton JM. Platelet Gel for Endoscopic Sinus Surgery. Ann Otol Rhinol Laryngol 2005;114:699-704 

Kanno T, Takahashi T, Tsujisawa T, Ariyoshi W, Nishihara T. Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. J Oral Maxillofac Surg 2005;63:362-369

2006
Schmidmaier G, Herrmann S, Green J, Weber T, Scharfenberger A, Haas NP, Wildemann B. Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone 2006;39:1156-1163

Lin SS, Landesberg R, Chin HS, Lin J, Eisig SB, Lu HH. Controlled release of PRP-derived growth factors promotes osteogenic differentiation of human mesenchymal stem cells. Conf Proc IEEE Eng Med Biol Soc. 2006;1:4358-4361

Ogino Y, Ayukawa Y, Kukita T, Koyano K. The contribution of platelet-derived growth factor, transforming growth factor-beta1, and insulin-like growth factor-I in platelet-rich plasma to the proliferation of osteoblast-like cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:724-729 

Lobmann T, Pap T, Ambrosch A, Waldmanna K, Königc W, Lehnert H. Differential effects of PDGF-BB on matrix metalloproteases and cytokine release in fibroblasts of Type 2 diabetic patients and normal controls in vitro. J Diabetes Complic 2006;20:105–112 

Savarino L, Cenni E, Tarabusi C, Dallari D, Stagni C et al. Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: a standardized methodology in patients with tibial osteotomy for genu varus. J Biomed Mater Res Part B: Appl Biomater 2006;76B:364–372 

Celotti F, Colciago A, Negri-Cesi P, Pravettoni A, Zaninetti R, Sacchi MC. Effect of platelet-rich plasma on migration and proliferation of SaOS-2 osteoblasts: role of platelet-derived growth factor and transforming growth factor-b. Wound Rep Reg 2006;14:195–202 

Akeda K, An KS, Pichika R, Attawia M, Thonar EJ-MA et al. Platelet-Rich Plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and anulus fibrosus cells cultured in alginate beads. SPINE 2006;31:959–966 

Leitner GC, Gruber R, Neumüller J, Wagner A, Kloimstein P, Höcker P, Körmöczi GF, Buchta C. Platelet content and growth factor release in platelet-rich plasma: a comparison of four different systems. Vox Sang 2006;91:135–139 

Driver VR, Hanft J, Fylling CP, Beriou JM. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manag 2006;52:68–87 

Brady C, Vang S, Christensen K, Isler J, Vollstedt K, Holt D. The Use of Autologous Platelet Gel in Bariatric Surgery. J Extra Corpor Technol 2006;38:161-164 

Everts PAM, Hoffmann J, Weibrich G, Mahoney CB, Schönberger JPAM, van Zundert A, Knape JTA. Differences in platelet growth factor release and leucocyte kinetics during autologous platelet gel formation. Transf Med 2006:16:363–368 

Brown SA, Appelt EA, Lipschitz A, Sorokin ES, Rohrich RJ. Platelet gel sealant use in rhytidectomy. Plast Reconstr Surg 2006;118:1019-1025 

Virchenko O, Aspenberg P. How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation Acta Orthop 2006;77:806-812

Park D-J, Choi, JH, Kim Y-Jm, Kim J-H, Kim K-T. Nasal augmentation using injectable alginate and mesenchymal stem cells in the rabbit . Am J Rhinol 2006;20:520-523

Pietramaggiori G, Kaipainen A, Czeczuga J, Wagner C, Orgill, Dennis P. Freeze-dried platelet-rich plasma shows beneficial healing properties in chronic wounds Wound Repair Reg 2006;14:573-580

Ito K, Yamada Y, Naiki T, Ueda M. Simultaneous implant placement and bone regeneration around dental implants using tissue-engineered bone with fibrin glue, mesenchymal stem cells and platelet-rich plasma. Clin Oral Implants Res 2006;17:579-586

Koffler BH. Autologous serum therapy of the ocular surface with novel delivery by platelet concentrate gel. Ocul Surf 2006;4:188-195.

Knox RL, Hunt AR, Collins JC, DeSmet M, Barnes S. Platelet-rich plasma combined with skin substitute for chronic wound healing: a case report. J Extra Corpor Technol 2006;38:260-264.

Christgau M, Moder D, Hiller KA, Dada A, Schmitz G, Schmalz G. Growth factors and cytokines in autologous platelet concentrate and their correlation to periodontal regeneration outcomes. J Clin Periodontol 2006;33:837-845

McAleer JP, Sharma S, Kaplan EM, Persich G. Use of autologous platelet concentrate in a nonhealing lower extremity wound. Adv Skin Wound Care 2006;19:354-363

Klayman MH, Trowbridge CC, Stammers AH, Wolfgang GL, Zijerdi DA, Bitterly TJ. Autologous platelet concentrate and vacuum-assisted closure device use in a nonhealing total knee replacement. J Extra Corpor Technol 2006;38:44-47.

VL, Holds JB, Hartstein ME, Rich RM, Davidson BR. Use of autologous platelet concentrate in blepharoplasty surgery. Ophthal Plast Reconstr Surg 2006;22:102-104.

Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Kasper K, Geerling G. Corneal epitheliotrophic capacity of three different blood-derived preparations. Investi Ophthalmol Visual Sci 2006;47:2438-2444

Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg 2006;118:147e-159e 

Mannai C. Early implant loading in severely resorbed maxilla using xenograft, autograft, and platelet-rich plasma in 97 patients. J Oral Maxillofac Surg 2006;64:1420-1426.

George Broughton G II, Janis JE, Attinger CE. A brief history of wound care. Plast Reconstr Surg 2006;117(Suppl.): 6S-11S 

Blus C, Szmukler-Moncler S. Split-crest and immediate implant placement with ultra-sonic bone surgery: a 3-year life-table analysis with 230 treated sites. Clin Oral Impl. Res 2006;17:700-707

Arnoczky SP. The future of meniscal repair, regeneration, and replacement. Proc t3th ESVOT CongressM, unich, 7th-10th September 2006:13 

Everts PA, Knape JT, Weibrich G, Schönberger JP, Hoffmann J, Overdevest EP, Box HA, van Zundert A. Platelet-rich plasma and platelet gel: a review. J Extra Corpor Technol 2006;38:174-187 

Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med 2006;34:1774-1778 

Wallace JL, Dicay M, McKnight W, Dudar GK. Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor. Br J Pharmacol 2006;148:274-278 

Carmona Ramirez JU. Use of autologous platelet concentrates for the treatment of musculoskeletal injuries in the horse. PhD Thesis, Faculty Vet. Med., University of Barcelona, Spain, 2006 

2007
Gardner MJ, Demetrakopoulos D, Klepchick PR, Mooar PA. The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty. Int Orthop. 2007;31:309-313

Lindeboom JAH, Mathura KR, Aartman IHA, Kroon FHM, Milstein DMJ, Ince C. Influence of the application of platelet-enriched plasma in oral mucosal wound healing. Clin Oral Impl Res 2007;18:133–139 

Smrke D, Gubina B, Domanović D, Rožman P. Allogeneic platelet gel with autologous cancellous bone graft for the treatment of a large bone defect. Eur Surg Res 2007;39:170–174 

Rutkowski JL, Fennell JW, Kern JC, Madison DE, Johnson DA. Inhibition of alveolar osteitis in mandibular tooth extraction sites using platelet-rich plasma. J Oral Implantol 2007;33:116-121 

Bielecki T, Gazdzik TS, Szczepanski T. Benefit of percutaneous injection of autologous platelet-leukocyte-rich gel in patients with delayed union and nonunion. Eur Surg Res 2008;40:289-296

Uggeri J, Belletti S, Guizzardi S, Poli T, Cantarelli S, Scandroglio R, Gatti R. Dose-dependent effects of platelet gel releasate on activities of human osteoblasts. J Periodontol 2007;78:1985-1991

Tunç I, Nesrin D; Betül IK. Demineralized freeze-dried bone allograft and platelet-rich plasma vs platelet-rich plasma alone in infrabony defects: a clinical and radiographic evaluation. Clin Oral Invest 2007;11:51-59

Nishimoto S, Oyama T, Matsuda K. Simultaneous concentration of platelets and marrow cells: A simple and useful technique to obtain source cells and growth factors for regenerative medicine Wound Repair Reg 2007;15:156-162

Márquez-de-Aracena R, Montero-de-Espinosa I, Muñoz M, Pereira G. Subconjunctival application of plasma platelet concentrate in the treatment of ocular burns. Preliminary results. Arch Soc Esp Oftalmol 2007;82:475-481

Papli R, Chen S. Surgical treatment of infrabony defects with autologous platelet concentrate or bioabsorbable barrier membrane: a prospective case series. J Periodontol 2007;78:185-193.

Jameson CA. Autologous platelet concentrate for the production of Platelet gel. Lab Med 2007;38:39-42 

Schnabel LV, Mohammed HO, Miller BJ, McDermott WG, Jacobson MS, Santangelo KS, Fortier LA. Platelet Rich Plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res 2007;25:230-240 

No Author Listed: Editorial. Feature: current insights on growth factor therapy Podiatry Today 2007;20:70-75 

Alio JL, Abad M, Artola A, Rodriguez-Prats JL, Pastor S, Ruiz-Colecha J. Use of autologous platelet-rich plasma in the treatment of dormant corneal ulcers. Ophthalmology 2007;114:1286-1293 

Lindeboom JA, Mathura KR, Aartman IH, Kroon FH, Milstein DM, Ince C. Influence of the application of platelet-enriched plasma in oral mucosal wound healing. Clin Oral Implants Res 2007;18:133-139.

Woodall J Jr, Tucci M, Mishra A, Benghuzzi H. Cellular effects of platelet rich plasma: a study on HL-60 macrophage-like cells. Biomed Sci Instrum 2007;43:266-271 

Ishida K, Kuroda R, Miwa M, Tabata Y, Hokugo A, Kawamoto T, Sasaki K, Doita M, Kurosaka M. The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel. Tissue Eng 2007;13:1103-1112 

Pappalardo S, Cappello V, Viglianisi A, La Ferla F, Crespi R, Gherone E. Platelet rich plasma in associazione con osso bovino e GBR stimola la rigenerazione ossea. Case report: analisi clinica, istologica e istomorfometrica. Implantologia Orale 2007;2:45-49 [Italian] 

Krasna M, Domanović D, Tomsic A, Svajger U, Jeras M. Platelet gel stimulates proliferation of human dermal fibroblasts in vitro. Acta Dermatovenerol Alp Panonica Adriat 2007;16:105-110 

Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg 2007;9:174-183 

Zavadil DP, Satterlee CC, Costigan JM, Holt DW, Shostrom VK. Autologous platelet gel and platelet-poor plasma reduce pain with total shoulder arthroplasty. J Extra Corpor Technol 2007;39:177-182

2008
Yamamiya K, Okuda K, Kawase T, Hata K, Wolff LF, Yoshie H. Tissue-engineered cultured periosteum used with platelet-rich plasma and hydroxyapatite in treating human osseous defects. J Periodontol 2008;79:811-818

Mazzucco L, Balbo V, Cattana E, Borzini P. Platelet-rich plasma and platelet gel preparation using Plateltex. Vox Sang 2008;94:202-208 

Mizuno D, Kagami H, Mizuno H, Mase J, Usami K, Ueda M. Bone regeneration of dental implant dehiscence defects using a cultured periosteum membrane. Clin Oral Implants Res 2008;19:289-294

Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, Nagae M, Arai Y, Kawata M, Kubo T. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 2008;215:837-845

Cieslik-Bielecka A, Bielecki T, Gazdzik TS, Cieslik T, Szczepanski T. Improved treatment of mandibular odontogenic cysts with platelet-rich gel. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:423-429. 

Li XH, Zhou X, Zeng S, Ye F, Yun JL, Huang TG, Li H, Li YM. Effects of intramyocardial injection of platelet-rich plasma on the healing process after myocardial infarction. Coron Artery Dis 2008;19:363-370

Cheng X, Lei D, Mao T, Yang S, Chen F, Wu W. Repair of critical bone defects with injectable platelet rich plasma/bone marrow-derived stromal cells composite: experimental study in rabbits. Ulus Travma Acil Cerrahi Derg 2008;14:87-95 

DePoi R, John V, Paez de Mendoza CY, Gossweiler MK. Development of an oro-antral fistula following sinus elevation surgery: a case report on management using platelet-rich plasma. J Indiana Dent Assoc 2007-2008 Winter;86:10-6

de Mos M, van der Windt AE, Jahr H, van Schie HT, Weinans H, Verhaar JA, van Osch GJ. Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 2008;36:1171-1178.

Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, Nagae M, Arai Y, Kawata M, Kubo T. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 2008;215:837-845

Naldini A, Morena E, Fimiani M, Campoccia G, Fossombroni V, Carraro F. The effects of autologous platelet gel on inflammatory cytokine response in human peripheral blood mononuclear cells. Platelets 2008;19:268-274

Dougherty EJ. An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers.  Adv Skin Wound Care 2008; 21: 568-575.

Englert SJ, Estep TH, Ellis-Stoll CC. Postoperative surgical chest and leg incision sites using platelet gel: a retrospective study. J Extra Corpor Technol. 2008; 40: 225-228.

O'Connell SM, Impeduglia T, Hessler K, Wang XJ, Carroll RJ, Dardik H. Autologous platelet-rich fibrin matrix as cell therapy in the healing of chronic lower-extremity ulcers. Wound Repair Regen. 2008; 16: 749-756.

Ranzato E, Patrone M, Mazzucco L, Burlando B. Platelet lysate stimulates wound repair of HaCaT keratinocytes. Br J Dermatol. 2008; 159: 537-545.

Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med. 2008; 1:1 65-714.

2009
Alsousou J, Thompson M, Hulley P, Noble A, Willett K.  The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg Br. 2009; 91: 987-996.

Cervelli V, Gentile P, Grimaldi M. Regenerative surgery: use of fat grafting combined with platelet-rich plasma for chronic lower-extremity ulcers. Aesthetic Plast Surg. 2009; 33: 340-345.

De Giacomo T, Diso D, Ferrazza G, Venuta F, Francioni F, Coloni GF. Successful treatment of infected residual pleural space after pulmonary resection with autologous platelet-leukocyte gel. Ann Thorac Surg. 2009; 88: 1689-1691.


DeRossi R, Coelho AC, Mello GS, Frazílio FO, Leal CR, Facco GG, Brum KB. Effects of platelet-rich plasma gel on skin healing in surgical wound in horses. Acta Cir Bras. 2009; 24: 276-81.

Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009; 27: 158-167.

Drengk A, Zapf A, Stürmer EK, Klaus Michael Stürmer KM, Frosch K-H. Influence of Platelet-Rich Plasma on Chondrogenic Differentiation and Proliferation of Chondrocytes and Mesenchymal Stem Cells. Cells Tissues Organs. 2009;189 : 317-326.

Gunaydin S,  McCusker K,  Sari T,  Zorlutuna Y. Autologous Platelet Gel for the Prevention of Sternal Wound Infection in Diabetic Patients Undergoing Bilateral Thoracic Artery Grafting.  45th Annual Meeting of the Society of Thoracic Surgeons, 2009; Abstract Book: 324.

Kazakos K, Lyras DN, Verettas D, Tilkeridis K, Tryfonidis M. The use of autologous PRP gel as an aid in the management of acute trauma wounds. Injury. 2009; 40:801-805.

Ling H, Ye L, Xiulian H, Yu Z, Hui W. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108: 707-713.


Martínez-Zapata MJ, Martí-Carvajal A, Solà I, Bolibar I, Angel Expósito J, Rodriguez L, García J. Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review. Transfusion. 2009; 49 :44-56.

Mazzucco L, Balbo V, Cattana E, Guaschino R, Borzini P. Not every PRP-gel is born equal. Evaluation of growth factor availability for tissues through four PRP-gel preparations: Fibrinet, RegenPRP-Kit, Plateltex and one manual procedure. Vox Sang. 2009; 97: 110-118.

Mehta SK, Breitbart EA, Berberian WS, Liporace FA, Lin SS. Bone and wound healing in the diabetic patient. Foot Ankle Clin. 2010; 15: 411-437.

Peerbooms JC, de Wolf GS, Colaris JW, Bruijn DJ, Verhaar JA. No positive effect of autologous platelet gel after total knee arthroplasty. A double-blind randomized controlled trial: 102 patients with a 3-month follow-up. Acta Orthop. 2009; 80: 557-562.

Ranzato E, Mazzucco L, Burlando B. Platelet derivatives: a new horizon in regenerative. In: Advances in Medicine and Biology. Volume 11; Chapter 1. Nova Science Publishers, 2009.

Simon BI, Zatcoff AL, Kong JJ, O'Connell SM. Clinical and Histological Comparison of Extraction Socket Healing Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) to Ridge Preservation Procedures Employing Demineralized Freeze Dried Bone Allograft Material and Membrane. Open Dent J. 2009; 3: 92-99.

Stammers AH, Trowbridge CC, Marko M, Woods EL, Brindisi N, Pezzuto J, Klayman M, Fleming S, Petzold J. Autologous platelet gel: fad or savoir? Do we really know? J Extra Corpor Technol. 2009; 41: P25-30.

2010
Balbo R, Avonto I, Marenchino D, Maddalena L, Menardi G, Peano G. Platelet gel for the treatment of traumatic loss of finger substance. Blood Transfus. 2010; 8: 255-259.

Bernuzzi G, Tardito S, Bussolati O, Adorni D, Cantarelli S, Fagnoni F, Rossetti A, Azzarone M, Ficarelli E, Caleffi E, Gazzola G, Franchini M. Platelet gel in the treatment of cutaneous ulcers: the experience of the Immunohaematology and Transfusion Centre of Parma. Blood Transfus. 2010; 8: 237-247.

Bosch G, van Schie HT, de Groot MW, Cadby JA, van de Lest CH, Barneveld A, van Weeren PR. Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo-controlled experimental study. J Orthop Res. 2010; 28: 211-217.


Filardo G, Kon E, Buda R, Timoncini A, Di Martino A, Cenacchi A, Fornasari PM, Giannini S, Marcacci M. Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. Published on line 2010 Aug 26; 2010 in press.


Frykberg RG, Driver VR, Carman D, Lucero B, Borris-Hale C, Fylling CP, Rappl LM, Clausen PA. Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series. Ostomy Wound Manage. 2010; 56: 36-44.


Gobbi A. New Possibilities for Cartilage Repair. Europ Musculoskel Rev. 2010; 5: xx–xx, in press

Gobbi A. New technology: Bio-orthopaedics. J Clin Rehabilit Tiss Engin Res, 2010: 14: xx-xx, in press

Gobbi A, Boldrini L, Espregueira-Mendes J. The use of platelet rich plasma for cartilage repair. In: Mats Brittberg, Andreas Imhoff, Henning Madry and Bert Mandelbaum: Cartilage repair. Chapter 13; DJO Publications, Guilford Surrey UK, 2010.

Gobbi A, Madry H, Peretti G. Future of cartilage treatment. In: Mats Brittberg, Andreas Imhoff, Henning Madry and Bert Mandelbaum: Cartilage repair. Chapter 20; DJO Publications, Guilford Surrey UK, 2010.

Kaux JF, Le Goff C, Seidel L, Péters P, Gothot A, Albert A, Crielaard JM.Étude comparative de cinq techniques de préparation plaquettaire ( platelet-rich plasma). [Comparative study of five techniques of preparation of platelet-rich plasma.] Pathol Biol (Paris). 2010, in press [Article in French]

Mazzucco L, Borzini P, Gope R. Platelet-derived factors involved in tissue repair-from signal to function. Transfus Med Rev. 2010; 24: 218-234.

Pedzisz P, Zgoda M, Kocon H, Benke G, Górecki A. Treatment of solitary bone cysts with allogenic bone graft and platelet-rich plasma. A preliminary report. Acta Orthop Belg. 2010; 76: 374-379.

Picardi A, Lanti A, Cudillo L, Cerretti R, Dentamaro T, De Angelis G, Ferraro A, Di Veroli A, Adorno G, Arcese W; Rome Transplant Network. Platelet gel for treatment of mucocutaneous lesions related to graft-versus-host disease after allogeneic hematopoietic stem cell transplant. Transfusion. 2010; 50: 501-506.

Scevola S, Nicoletti G, Brenta F, Isernia P, Maestri M, Faga A. Allogenic platelet gel in the treatment of pressure sore: a pilot study. Int. Wound J 2010; 7: 184-190

Chen TM, Tsai JC, Burnouf T. A novel technique combining platelet gel, skin graft, and fibrin glue for healing recalcitrant lower extremity ulcers. Dermatol Surg. 2010 Apr;36(4):453-60. Epub 2010 Feb 19.

2011

Treatment of recalcitrant ulcers with allogeneic platelet gel from pooled platelets in aged hypomobile patients

N. Greppi, L. Mazzucco, G. Galetti, F. Bona, E. Petrillo, C. Smacchia, E. Raspollini,
P. Cossovich, R. Caprioli, P. Borzini, P. Rebulla, M. Marconi.
Biologicals, 2011